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However, smokers absorb only part of the nicotine concentration present in a cigarette

First, chronic inflammationprimarily mediated by neutrophils and macrophagesdirectly damages the epithelium and extracellular matrix (ECM) through proteases (e.g., MMPs, elastase), chemokines, and reactive oxygen species, thereby promoting structural destruction and airway narrowing

, [] while there are a number of everyday activities that can expose people to CO, including passive smoking, environmental pollution, and occupational exposure, smoking is the most common factor contributing to high exposure levels

Cadmium and cadmium compounds can cause lung cancer and have been associated with kidney and prostate cancer